〔8〕Qi W.N scean.P.Effects of type Ⅱ collagen in chondrocyte r esponse to TGF-β regultion［J］.Exp-cell-Res,1998,241:142～150.

〔9〕Tommo TsvkAzAkⅠ.ToshIRO VSR,Effect of TGF-β on insuline -like growth factor-Ⅰ autorine/paracrine axis in cultured rat articular chond rocytes［J］.Exp-cell-Res,1994,215:9～16.

〔10〕Peter C,Yaeger,Tersel.Synthesis action of transform ing gr owth factor-β and insuline-like growth factor-Ⅰ induces expression of type Ⅱ collagen and aggrecan gene in adult human articular chondrocytes［J］.Exp-c ell-Res,1997,237:318～325.

〔11〕Firedini,Marrie1.Transforming growth factor-beta e xert op posite effects from interleukin-β on cultured rabbit articular chondrocytes th rough reductioin of interleukin receptor expression［J］.Arthrits & Rheumatism ,1993,36:44～50.

〔12〕Mordes TI,Robberts AB.Transforming growth factor-b eta reg ulates the metabolism of pretoglcans in bovine cartilage organ cultures［J］. J .Biochem,1988,263:282～290.

〔13〕Wu-LN,Zshikawa-Y,Effects of osteogenic protein-1 on the development and mineralization of primary cultured avain growth plate chondrocy tes modulation by remoic acid［J］.J Cell Biochem,1997,15:167～178.

〔14〕Erichso-DM,Harris-SE.Recombinant bone morphogenet ic prot ein-2 regulates costochondral growth plate chondrocytes and induce expression o f BMP-2 and BMP-2 in at a cell maturation-dependent on mone［J］.J orthop-R es,1997,15(3):37～60.

〔15〕Venezian-R,Shenker-BJ.Modulation of chondrocytes prolife ration by ascorbic acid and BMP-2［J］.J Cell-physiol,1998,174(3):331～341.

〔16〕Salter O.M,J.E.R obb,M.O.Wright.Electrophysiologica l respo nse of human bone cells to mechanical stimulation:evidence for special integrin function in mechanotransduction［J］.J Bone miner Res,1997,12(1):133～1 141.

〔17〕L.A.Durrant,C.W,Archer,Benjamzn.Organization of the chondr ocyte cytoskeleton and its response to changing mechanical conditions in organ c ulture［J］.J Ant,1999,194(4):53～60.

〔18〕Karin Holmvall,Lisbet Camper,Staffan.Chondrocyte an d chond rosarcoma cell integrin with affinity for collagen type Ⅱ and their response me chanical stress［J］.Exp Cell Res,1995,221:496～503.

〔19〕Andrewc.Hall,Differential effects of hydrostaic pre ssure o n cation transport pathway of isolated articular chondrocyte［J］.J Cell Physi ,1999,178:197～204.

〔20〕S.J.Millward-Sadler,M.O.wright,H.S.Lee.Integrin-r egulate d Secretion of interleukin 4,A novel pathwary of mechanotransduction in human ar ticular chondrocyte［J］.J cell Biol,1999,145(5):483～489.

〔21〕Shyy.J.S,chien;Role of integrins in cellular respon se to mechonical stress and adhesion［J］.Curr Opin Cell Biol,1997,9:707～713.

〔22〕Thomas.M,Quinn.Alan.J.Mechanical compression alter proteo glycan deposition and matrix deformation around individual cells in cartilage ex plants［J］.J Cell Sci,1998,111:573～583.

〔23〕Trkanaski-k,kubo-T.Hydrostatic pressure induces e xpression of interleukin-6